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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:

A) Schistosoma mekongi
B) Schistosoma mansoni
C) Schistosoma haematobium
D) Schistosoma japonicum

2. A clinical microbiology laboratory is validating a new automated blood culture system. To assess the system's ability to detect true positive results, they should:

A) Spike known concentrations of various microorganisms into blood culture bottles.
B) Process a large number of sterile blood samples.
C) Evaluate the system's performance with samples from patients with known bloodstream infections.
D) Compare the time to detection with the current manual blood culture method.

3. A Klebsiella pneumoniae isolate from a bloodstream infection shows the following susceptibility profile:
Meropenem (MIC = 8 µg/mL, R), Imipenem (MIC = 16 µg/mL, R), Ertapenem (MIC = 4 µg/mL, R), Ceftazidime/avibactam (MIC = 1 µg/mL, S), Aztreonam (MIC = 32 µg/mL, R). Which resistance mechanism is most strongly suggested by this pattern?

A) AmpC beta-lactamase hyperproduction coupled with porin loss
B) Extended-Spectrum Beta-Lactamase (ESBL) production alone
C) Klebsiella pneumoniae Carbapenemase (KPC) production
D) Metallo-beta-lactamase (MBL) production

4. A microbiology laboratory receives a sample of cerebrospinal fluid from a patient with suspected bacterial meningitis. The Gram stain shows Gram-positive diplococci. Culture on blood agar shows alpha-hemolytic colonies that are bile soluble and optochin-sensitive. The MOST likely organism is:

A) Streptococcus agalactiae
B) Enterococcus faecalis
C) Listeria monocytogenes
D) Streptococcus pneumoniae

5. A patient with HIV infection and a CD4+ T-cell count below 50 cells/µL develops a progressive neurological illness characterized by confusion, motor deficits, and seizures. Brain MRI reveals multiple white matter lesions without mass effect. PCR of the CSF is positive for JC virus. Thepathogenesis of this condition, progressive multifocal leukoencephalopathy (PML), involves:

A) Opportunistic infection by JC virus due to impaired cell-mediated immunity.
B) Direct cytopathic effect of JC virus on neurons.
C) Inflammatory demyelination triggered by JC virus infection of astrocytes.
D) Lytic infection of oligodendrocytes by JC virus, leading to demyelination.

Solutions: